Detailed examination of the dams was performed. In an attempt to limit emnbryolethality and thereby promote detection of terata, CSO was administered once daily for a limited period of gestation i, via dermal application, to pregnant Sprague-Dawley rats at doses of 0, 10, 100, and 1000 mg/kg. The present study was undertaken to further explore the teratogenic potential of CSO. The manifestations of developmental toxicity observed included embryolethlity and growth retardation evidence of teratogenicity was limited, and not conclusive. [Stonybrook Laboratories, Inc., Princeton, NJ (United States)Ĭlarified slurry oil ( CSO, CAS number 6), a refinery stream produced by processing crude oil, is a developmental toxicant when administered dermally throughout gestation to pregnant rats. Developmental toxicity study in rats exposed dermally to clarified slurry oil for a limited period of gestationĮnergy Technology Data Exchange (ETDEWEB)įeuston, M.H.
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